BioRN Lounge welcomed Prof. Steffen Rupp from Fraunhofer IGB
BioRN Lounge: Prof. Steffen Rupp from Fraunhofer IGB talked about: ”Innate Immunity in 3D-Infection models: From simple Screening Systems to complex Immune Cell supplemented Skin Models”
Once again, the BioRN Lounge was the occasion for the life science companies as well for scientists from our research institutes, to meet and chat about latest news and achievements. The BioRN Lounge is the prime monthly networking event for BioRN members. It is the occasion for exchange, meeting and interaction in a very relaxed atmosphere with some drinks and food.
In addition, an invited speaker from the network presents and discusses with the participants, scientific trends, outbreaking techniques, outstanding research and more. Yesterday, we welcomed Prof. Steffen Rupp, who is deputy director of Fraunhofer IGB and Head of the Department of Molecular Biotechnology.
Fraunhofer IGB is one of 72 institutes and independent research units of the Fraunhofer-Gesellschaft, which is active in following fields of competence: Interfacial Engineering and Materials Science, Molecular Biotechnology, Physical Process Technology, Environmental Biotechnology and Bioprocess Engineering, as well as Cell and Tissue Engineering
Prof. Steffen Rupp provided to the audience a short overview of the research activities and institute structures of Fraunhofer IGB and then focused on the scientific part of his presentation. The presentation covered the generation of simple cell-based screening systems and their integration into complex skin models. Prof. Steffen Rupp could present recent results from these 3D skin models in the elucidation of cellular communication for activation of effective defense mechanisms in the presence of microbial pathogens.
“For screening platforms and diagnostics you have to simplify your assay.”
“We design the in vitro models as close as possible to nature, which is a challenge.”
The audience was particularly interested in the potential of 3D skin models for in vitro test screens and drug discovery. Prof. Steffen Rupp pointed out that a huge potential of in vitro cell culture tissue models is the possibility to analyze cell-cell communication mechanisms in human 3D tissue systems in detail and to understand how they are organized. This will identify new drug targets and may lead to new therapeutic approaches, e.g. stimulating the protective mechanisms already present in the tissue or organism. Another topic of interest was the role of commensal microorganisms (skin flora) in the described defense mechanisms of the skin.
BioRN is a life science research and industry cluster dedicated to the development of cell-specific, molecular and personalised innovative treatments. The BioRN Cluster stands for the development, networking, representation and promotion of the life science region into one of the leading life science clusters in Europe.
The cluster-members include renowned academic research institutions such as the Universities of Heidelberg, the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL) and big pharmaceutical companies such as AbbVie, Boehringer Ingelheim, Johnson & Johnson, Merck, Roche, und Sanofi-Aventis, and about 80 small and medium-sized biotech enterprises. Beyond the members registered in the cluster, BioRN gives access to a wider network via partnerships and collaborations.
In terms of the use of clusters for the internationalization of companies, BioRN has founded, together with Leuven (Belgium), Maastricht (Netherlands) and Copenhagen (Denmark), an alliance for the enforcement of biomedical innovation in Europe, called the Health Axis Europe.
About Fraunhofer IGB
Fraunhofer IGB develops and optimizes technologies, processes and products for the business areas of health, chemistry and process industry as well as environment and energy. Fraunhofer IGB combines the highest scientific quality with professional know-how in its fields of competence – Interfacial Engineering and Materials Science, Molecular Biotechnology, Physical Process Technology, Environmental Biotechnology and Bioprocess Engineering, as well as Cell and Tissue Engineering – always with a view to economic efficiency and sustainability.
The strengths of Fraunhofer IGB lie in offering complete solutions from laboratory to pilot plant scale. Customers also benefit from the cooperation between five R&D departments in Stuttgart and the institute branches located in Leuna and Straubing. The constructive interplay of the various disciplines at the institute opens up new approaches in areas such as medical engineering, nanotechnology, downstream processing and environmental technology. Fraunhofer IGB is one of 72 institutes and independent research units of the Fraunhofer-Gesellschaft, Europe’s leading organization for applied research.