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HITS: Force for Activation

On March 20, 2019, Posted by , In News, By , , With Comments Off on HITS: Force for Activation

 Tumor invasion and metastasis are major problems in the therapy of cancer patients. A team of researchers at the Heidelberg Institute of Theoretical Studies (HITS), the LMU Munich (both Germany) and the CNIO Madrid, Spain, has now elucidated the activation conditions for a key enzyme in this process – a…

From mirror-image biology to enhanced therapeutic proteins

On March 15, 2019, Posted by , In News, By , With Comments Off on From mirror-image biology to enhanced therapeutic proteins

Hands – a prime example of mirror-image biology © Adobe Stock Almost all biological molecules exist as two different spatial structures that are related to each other like image and mirror image. These molecules are referred to as enantiomers. Much like one’s right and left hands, they cannot be superimposed…

New member: Welcome in our cluster to Yumab

On March 13, 2019, Posted by , In News, By , With Comments Off on New member: Welcome in our cluster to Yumab

We are happy to welcome in our cluster Yumab:   YUMAB develops fully human antibodies from target to lead for clients and partners worldwide. Its proprietary antibody platform covers all technologies from antibody discovery – using one of the world’s largest, natural human antibody library collection (>10e11) or customized, patient-derived…

EMBL-GSK: ATP affects proteome-wide solubility

On March 11, 2019, Posted by , In News, By , , With Comments Off on EMBL-GSK: ATP affects proteome-wide solubility

ATP affects the solubility of many proteins that make up membraneless organelles like the one visualised here. IMAGE: Sarah Nguyen/EMBL   Scientists develop technology to measure how ATP concentration affects protein solubility in cells A collaboration between EMBL Heidelberg’s Savitski team and GSK’s Cellzome has developed a new technology to study how…

HITS: Metabolic signaling as new concept for breast cancer risk estimation

On March 6, 2019, Posted by , In News, By , With Comments Off on HITS: Metabolic signaling as new concept for breast cancer risk estimation

HITS is partner of the international research consortium “MESI-STRAT” that explores the interplay of breast cancer metabolism and oncogenic signaling by systems medicine. The consortium was awarded by the European Union €6 million for five years. The main goal of the five-years project is to develop new models for knowledge-based…

DKFZ: Protein content as a marker for response to therapy in brain cancer

On March 6, 2019, Posted by , In News, By , , With Comments Off on DKFZ: Protein content as a marker for response to therapy in brain cancer

Brain tumors vary widely in how they respond to treatment. However, early assessment of therapy response is essential in order to choose the best possible treatment for the patient. Scientists from the German Cancer Research Center (DKFZ) have now been able to show in a study using non-invasive high-resolution 7-Tesla…

German Cancer Award 2019: Michael Platten, Ugur Sahin, Roland Rad and Dieter Saur were honoured for their pioneering work in oncology.

On March 1, 2019, Posted by , In News, By , With Comments Off on German Cancer Award 2019: Michael Platten, Ugur Sahin, Roland Rad and Dieter Saur were honoured for their pioneering work in oncology.

v.l. Prof. Dieter Saur (München), Prof. Michael Platten (Mannheim/Heidelberg), Prof. Ugur Sahin (Mainz) und Prof. Roland Rad (München). © EMBL Photolab The German Cancer Award, sponsored by the German Cancer Society and the German Cancer Foundation, is one of the highest awards in German cancer medicine. In the “Clinical Research”…

Roche enters into definitive merger agreement to acquire Spark Therapeutics

On March 1, 2019, Posted by , In News, By , With Comments Off on Roche enters into definitive merger agreement to acquire Spark Therapeutics

Roche to acquire Spark Therapeutics for US$ 114.50 per share Spark Therapeutics is a leader in discovering, developing and delivering gene therapies with one commercial asset and four programmes currently in clinical trials Transaction expected to close in Q2, 2019 Roche (SIX: RO, ROG; OTCQX: RHHBY) and Spark Therapeutics, Inc….

DKFZ: Inflammation signals induce dormancy in aging brain stem cells

On March 1, 2019, Posted by , In News, By , With Comments Off on DKFZ: Inflammation signals induce dormancy in aging brain stem cells

In old age, the amount of stem cells in the brains of mice decreases drastically. The remaining ones protect themselves from completely vanishing by entering a state of dormancy, scientists from the German Cancer Research Center (DKFZ) have now reported in “CELL”. The old stem cells are hard to awaken,…

EMBL: Many gut microbes may originate in the mouth

On March 1, 2019, Posted by , In News, By , With Comments Off on EMBL: Many gut microbes may originate in the mouth

  Scientists compared the microbial genes in saliva and stool samples and found many similarities. IMAGE: Sebastian Schmidt/EMBL Even in healthy people, many oral microbes traverse the gastrointestinal tract and colonise the gut Scientists from EMBL’s Bork group, in collaboration with the Zeller team and the Luxembourg Centre for Systems…