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DKFZ Nobel Laureate Lecture Series: Sir Paul Nurse – Nobel Laureate in Medicine or Physiology 2001
27. October 2017 @ 17:00 - 19:00
October 27, 2017 at 5 p.m. – Lecture Hall, DKFZ Communication Center
Controlling the Cell Cycle
Both S-phase and mitosis are common to all cell cycles and both are necessary for the two newly divided cells to receive a full complement of genes. In fission yeast the onset of S-phase and mitosis can be controlled by a single cyclin dependent kinase with different levels of CDK activity bringing about progression through the cell cycle in an orderly fashion. Using phosphoproteomics we show that a low CDK activity is sufficient to bring about S-phase whilst a high activity blocks a further S-phase and is needed for onset of mitosis. A G2 cell can be programmed to undergo either S-phase or mitosis simply by modifying CDK activity indicating there is no inherent direction in the cell cycle.
Sir Paul Nurse is a geneticist and cell biologist who has worked on how the eukaryotic cell cycle is controlled and how cell shape and cell dimensions are determined. His major work has been on the cyclin dependent protein kinases and how they regulate cell reproduction. He is Director of the Francis Crick Institute in London, and has served as President of the Royal Society, Chief Executive of Cancer Research UK and President of Rockefeller University. He shared the 2001 Nobel Prize in Physiology or Medicine and has received the Albert Lasker Award and the Royal Society’s Royal and Copley Medals. He was knighted in 1999, received the Legion d’honneur in 2003, and for 15 years was a member of the Council for Science and Technology advising the UK Prime Minister and Cabinet concerning science and innovation issues, and is now a member of the EU Scientific Advice Mechanism.
PUBLIC LECTURE – NO REGISTRATION FEE