Solmic Research GmbH and the European Molecular Biology Laboratory enter into a research collaboration
Solmic Research GmbH has entered into a research collaboration with the European Molecular Biology Laboratory (EMBL) with the goal to elucidate the mode of action of natural extracts.
Natural extracts, such as active ingredients of plants, are the origin of medicine and are widely used for medical applications, especially in China, where they play a central role in Traditional Chinese Medicine (TCM). However, despite empirical evidence over thousands of years, molecular mechanisms for the effectiveness of TCM in the treatment of various diseases are still lacking in most cases.
Natural extracts pose additional challenges, including lack of standardization, limited stability and insufficient water-solubility for use in biological assays to achieve reliable results. Moreover, complex extracts, often including dozens of different ingredients, are broadly active in a panoply of assays, making it impossible to determine modes of action by conventional methods.
SolMic Research and EMBL now combine their strengths in a collaboration to conduct mode of action studies for selected plant extracts employed in TCM.
SolMic´s proprietary technology portfolio allows the stable preparation of water-soluble extracts containing water-soluble and -insoluble ingredients.
Prof. Matthias Hentze, EMBL Director, works in the fields of molecular medicine, systems and RNA biology. His lab developed the method of enhanced RNA Interactome Capture (eRIC) that allows for the highly parallel investigation of responses by RNA-binding proteins. Applied to SolMic’s extracts, eRIC could deliver important information on molecular pathways affected by the application of the selected extracts.
This collaboration is transacted by EMBL Enterprise Management Technology Transfer GmbH (EMBLEM) the wholly-owned technology transfer arm of EMBL.
“SolMic has found a key to overcome a critical limitation for the molecular characterization of the modes of action of TCM extracts: reliable and reproducible water-solubility of the components to be studied” says Professor Matthias Hentze. “We are excited to apply EMBL’s methodologies, including proprietary technology developed by my laboratory, to unlock some of TCM’s secrets.”
“We are excited to join forces with EMBL, to tackle the challenge of establishing a strong scientific rationale for the use of traditional herbal medicines in the treatments for diseases in the fields of cancer, inflammation and metabolic disorders”, said Dr. Wolfgang Schönfeld, CEO of SolMic Research.
Original Press Release.