DKFZ: The development of brain stem cells into new nerve cells and why this can lead to cancer

On February 6, 2019, Posted by , In News, By , , With Comments Off on DKFZ: The development of brain stem cells into new nerve cells and why this can lead to cancer

Stem cells are true “Jacks-of-all-trades” of our bodies, as they can turn into the many different cell types of all organs. This allows the tissues such as muscle or even brain to renew and to heal after injury. This amazing “multipotency” makes stem cells in the adult body key tools…

DKFZ: A major step towards digital oncology

On January 24, 2019, Posted by , In News, By , , With Comments Off on DKFZ: A major step towards digital oncology

Methods of artificial intelligence (AI) such as deep learning using neural networks are gaining increasing importance in health research and personalized medicine. In oncology, new experimental and diagnostic methods such as genome sequencing and whole-body imaging by magnetic resonance imaging are also generating growing amounts of data. © Fotolia Using…

DKFZ-Vaccination as a therapy: Experimental vaccine against cervical cancer successfully tested in mice

On January 23, 2019, Posted by , In News, By , , With Comments Off on DKFZ-Vaccination as a therapy: Experimental vaccine against cervical cancer successfully tested in mice

Scientists from the German Cancer Research Center (DKFZ) have developed an experimental vaccine to fight cervical cancer caused by human papillomaviruses (HPV). This has already been accomplished successfully in mice. Tumors regressed in half of the vaccinated animals. The scientists’ goal is to develop a therapeutic vaccine for people who…

HI-STEM/DKFZ: Human blood cells can be directly reprogrammed into neural stem cells

On December 21, 2018, Posted by , In News, By , , With Comments Off on HI-STEM/DKFZ: Human blood cells can be directly reprogrammed into neural stem cells

Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early…

DKFZ/EMBL: New Ways to Look at Protein-RNA Networks

On December 10, 2018, Posted by , In News, By , , With Comments Off on DKFZ/EMBL: New Ways to Look at Protein-RNA Networks

For their vital tasks, all RNA molecules in our cells require proteins as binding partners. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and colleagues from the European Molecular Biology Laboratory (EMBL) have developed the first method with which they can analyze the composition of the entire RNA-protein…

DKFZ/EMBL: Algorithm identifies multiple gene–environment relationships

On November 30, 2018, Posted by , In News, By , , With Comments Off on DKFZ/EMBL: Algorithm identifies multiple gene–environment relationships

Researchers at the German Cancer Research Center (DKFZ), EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Wellcome Sanger Institute have developed a new computational method that makes it possible to identify the impact of hundreds of environmental factors on genotype–environment interactions. The method will enhance understanding of relationship between genotype and…

DKFZ: Defective DNA damage repair leads to chaos in the genome

On November 14, 2018, Posted by , In News, By , , With Comments Off on DKFZ: Defective DNA damage repair leads to chaos in the genome

Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation…

A faster lane towards effective therapies of childhood brain cancer

On November 6, 2018, Posted by , In News, By ,, , With Comments Off on A faster lane towards effective therapies of childhood brain cancer

Scientists of the „Hopp Children’s Cancer Center at the NCT Heidelberg” (KiTZ), the German Cancer Consortium (DKTK) and the German Cancer Research Center (DKFZ), in collaboration with colleagues from Seattle, U.S.A., have built a collection of tumor models that can be used to test anticancer drugs for treating childhood brain…

DKFZ/HI-STEM – Breast cancer: Stress signaling promotes metastasis and therapy resistance

On November 6, 2018, Posted by , In News, By , , With Comments Off on DKFZ/HI-STEM – Breast cancer: Stress signaling promotes metastasis and therapy resistance

Scientists from the German Cancer Research Centre (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) have identified a central switch protein in breast cancer that promotes tumor metastasis in response to cellular stress. The switch triggers a stem cell program in the cancer cells…

DKFZ: Takeda Oncology Research Award 2018 to Rocio Sotillo

On October 19, 2018, Posted by , In News, By ,, , With Comments Off on DKFZ: Takeda Oncology Research Award 2018 to Rocio Sotillo

A certain form of lung cancer is characterized by two genes that are accidentally fused. The fusion produces a growth signal for the cells. These tumors respond well to a targeted drug that deprives the cancer cells of the growth stimulus. Several molecular variants of cancer-promoting gene fusion exist. Rocio…