DKFZ/EMBL: New Ways to Look at Protein-RNA Networks

On December 10, 2018, Posted by , In News, By , , With Comments Off on DKFZ/EMBL: New Ways to Look at Protein-RNA Networks

For their vital tasks, all RNA molecules in our cells require proteins as binding partners. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and colleagues from the European Molecular Biology Laboratory (EMBL) have developed the first method with which they can analyze the composition of the entire RNA-protein…

DKFZ/EMBL: Algorithm identifies multiple gene–environment relationships

On November 30, 2018, Posted by , In News, By , , With Comments Off on DKFZ/EMBL: Algorithm identifies multiple gene–environment relationships

Researchers at the German Cancer Research Center (DKFZ), EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Wellcome Sanger Institute have developed a new computational method that makes it possible to identify the impact of hundreds of environmental factors on genotype–environment interactions. The method will enhance understanding of relationship between genotype and…

DKFZ: Defective DNA damage repair leads to chaos in the genome

On November 14, 2018, Posted by , In News, By , , With Comments Off on DKFZ: Defective DNA damage repair leads to chaos in the genome

Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation…

A faster lane towards effective therapies of childhood brain cancer

On November 6, 2018, Posted by , In News, By ,, , With Comments Off on A faster lane towards effective therapies of childhood brain cancer

Scientists of the „Hopp Children’s Cancer Center at the NCT Heidelberg” (KiTZ), the German Cancer Consortium (DKTK) and the German Cancer Research Center (DKFZ), in collaboration with colleagues from Seattle, U.S.A., have built a collection of tumor models that can be used to test anticancer drugs for treating childhood brain…

DKFZ/HI-STEM – Breast cancer: Stress signaling promotes metastasis and therapy resistance

On November 6, 2018, Posted by , In News, By , , With Comments Off on DKFZ/HI-STEM – Breast cancer: Stress signaling promotes metastasis and therapy resistance

Scientists from the German Cancer Research Centre (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) have identified a central switch protein in breast cancer that promotes tumor metastasis in response to cellular stress. The switch triggers a stem cell program in the cancer cells…

DKFZ: Takeda Oncology Research Award 2018 to Rocio Sotillo

On October 19, 2018, Posted by , In News, By ,, , With Comments Off on DKFZ: Takeda Oncology Research Award 2018 to Rocio Sotillo

A certain form of lung cancer is characterized by two genes that are accidentally fused. The fusion produces a growth signal for the cells. These tumors respond well to a targeted drug that deprives the cancer cells of the growth stimulus. Several molecular variants of cancer-promoting gene fusion exist. Rocio…

DKFZ: Machine Learning to Accellerate Drug Research

On October 10, 2018, Posted by , In News, By , , With Comments Off on DKFZ: Machine Learning to Accellerate Drug Research

The European Research Council (ERC) is awarding a “proof-of-concept grant” to scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Heidelberg University for the first time to enable them to develop new drugs more cheaply and quickly using image-based analyses. Automated microscopy documents changes in cells after…

Breast cancer: Towards individualized therapy

On October 8, 2018, Posted by , In News, By , , With Comments Off on Breast cancer: Towards individualized therapy

Breast cancer is as manifold as are those who are affected. Therefore, scientists and physicians from the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and the National Center for Tumor Diseases (NCT) in Heidelberg are generating genetic profiles from metastatic tissue samples before they choose, on this basis,…

DKFZ: Sugar metabolism controls intestinal regeneration

On September 19, 2018, Posted by , In News, By , , With Comments Off on DKFZ: Sugar metabolism controls intestinal regeneration

Scientists from the German Cancer Research Center and Heidelberg University have discovered a surprising connection between sugar metabolism and the adaptation of intestinal tissue to the nutritional state. Section from the intestine of a fruit fly: Stem cells are labelled green (GFP). © M. Boutros/DKFZ No other tissue in our…

DKFZ: A healthy lifestyle reduces the risk of colon cancer – regardless of the genetic risk profile

On September 18, 2018, Posted by , In News, By , , With Comments Off on DKFZ: A healthy lifestyle reduces the risk of colon cancer – regardless of the genetic risk profile

The risk of developing bowel cancer depends, among other things, on lifestyle. Scientists from the German Cancer Research Center were able to show that everyone can reduce their personal risk of colon cancer by combining as many of five healthy lifestyles as possible: non-smoking, low alcohol consumption, a healthy diet,…