DKFZ / Malaria: Cooperating antibodies enhance immune response

On June 11, 2018, Posted by , In News, By , , With Comments Off on DKFZ / Malaria: Cooperating antibodies enhance immune response

Malaria is one of the most inflicting infectious diseases worldwide. Scientists from the German Cancer Research Center (DKFZ) in Heidelberg, Germany, and from The Hospital for Sick Children (SickKids) in Toronto, Canada, have studied how the human immune system combats malaria infections. In this study, the researchers discovered a previously…

DKFZ: Breast cancer – Microproteins essential for cancer growth

On June 1, 2018, Posted by , In News, By ,, , With Comments Off on DKFZ: Breast cancer – Microproteins essential for cancer growth

Breast cancer is one of the leading causes of death in women worldwide. In order to develop new therapies, it is necessary to understand exactly how breast cancer cells function. Scientists at the German Cancer Research Center have taken an important step in this direction: In tumor tissue from breast…

BioMed X and Merck extend research collaboration in oncology

On May 8, 2018, Posted by , In News, By ,, , With Comments Off on BioMed X and Merck extend research collaboration in oncology

BioMed X announced the start of a new research project in collaboration with Merck at its Innovation Center in Heidelberg. The new team will focus on the identification of novel approaches to exploit tumor-specific RNA splicing alterations for targeted cancer therapy.     Dr. Jan Mauer, who joined the BioMed X…

EMBL – CRISPR: from clipping scissors to word processor

On May 8, 2018, Posted by , In News, By ,, , With Comments Off on EMBL – CRISPR: from clipping scissors to word processor

Barcodes are used in a new way in the MAGESTIC platform, adding a new level of precision to CRISPR gene editing. Credit: Kelly Irvine/NIST Using the gene-editing tool CRISPR to snip at DNA is often akin to using scissors to edit a newspaper article. You can cut out words, but it’s…

EMBL: Protein stability and solubility during cell cycle

On May 3, 2018, Posted by , In News, By , , With Comments Off on EMBL: Protein stability and solubility during cell cycle

  Dividing cell colored in a heat gradient, highlighting the variation in proteins’ thermal stability within and between different cell cycle stages. IMAGE: Aleksandra Krolik / EMBL EMBL scientists uncover large solubility and thermal stability changes of proteins during cell cycle The cell cycle is a highly dynamic process that…

University Hospital HD / Sumaya Biotech: New vaccine candidate against malaria successfully tested in first clinical trial

On May 2, 2018, Posted by , In News, By , , With Comments Off on University Hospital HD / Sumaya Biotech: New vaccine candidate against malaria successfully tested in first clinical trial

A novel vaccine candidate against the causative agent of malaria tropica, the most severe form of human malaria, has now been successfully tested for safety, tolerability and immunogenicity (ability to produce antibodies). Experts of the Department of Clinical Pharmacology and Pharmacoepidemiology of the University Hospital Heidelberg (directed by Prof. Dr….

Cleavage Product of Alzheimer’s Key Protein APP Stimulates Nerve Cell Communication

On April 17, 2018, Posted by , In Research Article, By ,, , With Comments Off on Cleavage Product of Alzheimer’s Key Protein APP Stimulates Nerve Cell Communication

Neuroprotective role of APPsα: A histological section through the hippocampus is depicted in the background. The red staining shows APPsα in neuronal cell bodies. The green staining shows the dendritic processes of nerve cells. Source: Max Richter, Müller research group A cleavage product of the Alzheimer’s APP protein stimulates nerve…

DKFZ: Blood test indicates risk of developing Alzheimer’s disease

On April 9, 2018, Posted by , In Research Article, By ,, , With Comments Off on DKFZ: Blood test indicates risk of developing Alzheimer’s disease

A newly developed blood test may indicate Alzheimer’s disease on average eight years before the clinical diagnosis. This was demonstrated by scientists from the Ruhr University Bochum (RUB), the German Cancer Research Center (DKFZ) and the Saarland Cancer Registry with a large population-based cohort study from the Saarland. Pathological deposits…

EMBL: microglia nibbling on brain synapses (captured on film)

On March 27, 2018, Posted by , In Research Article, By ,, , With Comments Off on EMBL: microglia nibbling on brain synapses (captured on film)

For the first time, EMBL researchers have captured microglia nibbling on brain synapses. Their findings show that the special glial cells help synapses grow and rearrange, demonstrating the essential role of microglia in brain development. Nature Communications publishes the results on March 26. Multiple synapse heads send out filopodia (green)…

EMBL: Potential new way to limit antibiotic resistance spreading

On March 19, 2018, Posted by , In Research Article, By , , With Comments Off on EMBL: Potential new way to limit antibiotic resistance spreading

Potential new way to limit antibiotic resistance spreading. IMAGE: Aleksandra Krolik / EMBL EMBL scientists unravel the molecular basis of a major antibiotic resistance transfer mechanism One of the biggest current threats to global health is the rise of multi-drug resistant bacteria, caused by the spreading of antibiotic resistance amongst…