Research

How can effective treatments for neuropsychiatric disorders be developed without having to accept unwanted side effects? Researchers at the NMI have made an important contribution to this field. In their recent paper, “NMDA receptor subtype differential affinity as a key enabler for precision neuropsychiatry,” they demonstrate how specifically targeting subunits of the NMDA receptor opens […]

Scientists find that close interactions between the mechanical properties of tissues and biochemical signalling between cells drive critical cell fate decisions during zebrafish embryo development Summary Embryonic development is one of the most dynamic biological processes in nature. Cells and tissues organise and reorganise themselves following incredibly precise patterns, while remaining flexible and robust. Scientists […]

Rodríguez-Correa, E., Grünschläger, F., Nizharadze, T. et al. A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells. Nat Cell Biol (2026). https://doi.org/10.1038/s41556-026-01958-0 https://www.nature.com/articles/s41556-026-01958-0 Abstract Haematopoietic stem cells (HSCs) display extensive molecular and functional heterogeneity. However, a cohesive model that explains the relationship and biological relevance of these diverse HSC states remains elusive. Here, […]

NK Cell Immunotherapy offers New Hope for Fibrosis Research jointly led by scientists at the Heidelberg site of the German Center for Lung Research and investigators in Boston at Massachusetts General Hospital and Harvard Medical School identifies a new immunotherapy-based approach for lung fibrosis: reactivating natural killer cell (NK cells) to eliminate senescent fibroblasts, reverse […]

In a paper newly published in mAbs, Universität Stuttgart-, Technical University of Braunschweig-, and YUMAB GmbH-based authors reveal research results for novel antagonistic anti-EGFR antibodies that have potential to overcome resistance to current T-cell engagers against the same target. ABSTRACT Epidermal growth factor receptor (EGFR) is a validated therapeutic target in several human cancers harboring […]

Nature Neuroscience study identifies human plaque-associated microglia using deep learning-based cell segmentation

Researchers’ newest technologies allow them to discover tiny protein that plays a big role in awakening dormant cells when it’s safe to resume normal operations Summary It’s a tough world for microbes. When resources grow limited and environments worsen, microbes have figured out ways to hunker down and go dormant until conditions improve. However, scientists […]

An international consortium has found over 1,700 new proteins from noncoding DNA, many of which show potential as targets for cancer immunotherapy In a collaborative effort, scientists in the TransCODE consortium reveal more than 1,700 new proteins that could have implications for human diseases, including cancer. These tiny proteins were found in what’s called the […]

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). They show that there are not just one, but four different subtypes of leukemia stem cells. This diversity could explain why one of the most important […]