Research

Researchers and physicians at the Hopp Children’s Cancer Center Heidelberg (KiTZ) and other leading cancer centers report an exceptional treatment success in an adolescent with an advanced, therapy-resistant kidney tumor. Using a novel, personalized T-cell therapy, they succeeded in completely pushing back the tumor disease despite multiple metastases. The individual compassionate-use treatment has now been […]

Electrospun fibers open up a wide range of possibilities in regenerative medicine and for in vitro testing. A key factor in ensuring success is replicating the natural extracellular matrix (ECM) as closely as possible. Electrospun fibers play a significant role in this regard due to their nanofiber structure. In a recent review article, Julia Schütz, […]

A team at KIT has developed a solution that significantly improves novel biosensors for medical use and enables faster diagnosis of infectious diseases Rapid, straightforward and, at the same time, accurate diagnosis of highly contagious pathogens such as the SARS-CoV-2 virus, which caused the coronavirus pandemic, is crucial to curbing the spread of disease. This […]

Researchers use synthetic biology approaches to test hundreds of DNA sequences for their effect on regulating gene expression Summary The human genome contains over 20,000 genes. However, at any given time and in a given cell, only a fraction of them are active. Researchers from EMBL Heidelberg’s Krebs Group have come up with an innovative […]

Researchers have discovered a previously unknown layer of control over DNA repair in cells, exerted from outside the nucleus Summary Our DNA is under constant threat. Chemicals, radiation, and the everyday errors of cell division all damage it, and if left unrepaired, this can lead to diseases such as cancer. Cells invest heavily in finding […]

An open-source analysis framework developed by researchers at EMBL, HHU, and other institutions makes it easier to study how cells are organised within tumours, paving the way for new insights into cancer biology Summary How cancer develops and responds to treatment depends not only on the tumour cells themselves but also on the complex ecosystem […]

International research team simulates motions of a hydrated proton in full quantum detail Complex simulations – the most intricate of their kind to date – reveal how water governs the way protons move through it. They were carried out by an international research team led by scientists of Heidelberg University’s Institute for Physical Chemistry. Using […]

Why do cancers develop differently in different people—even when they are exposed to the same risk factors? An international research group, including the German Cancer Research Center (DKFZ), has now demonstrated in mice that an organism’s genetic makeup significantly influences the course of cancer development. The findings, now published in Nature, provide new insights into […]

Researchers have designed synthetic and inducible proteins that bind to bright fluorescent dyes with high specificity and affinity, significantly expanding the toolkit for multicolour imaging of proteins inside cells Summary Cells are like metropolises, home to millions of molecular residents. If one were to stand atop a high-rise, trying to identify most of its inhabitants […]