Research

Cachexia is a metabolic disorder that causes uncontrolled weight loss and muscle wasting in chronic diseases and cancer. A new study by Helmholtz Munich, in collaboration with the Institute of Physiology of the Czech Academy of Sciences in Prague, Heidelberg University Hospital, the German Center for Diabetes Research (DZD), and the German Center for Cardiovascular […]

Inflammation has to work fast against pathogens—but it can’t get out of control. Researchers at the German Cancer Research Center (DKFZ) have now deciphered in more detail how the organism masters this balancing act. Their work shows that cells use two different strategies to precisely control inflammatory genes and thus precisely regulate the inflammatory response. […]

Bayer bolsters development portfolio by acquisition of two investigational imaging agents (AT-01 and AT-05) from Attralus, Inc. to advance diagnosis for cardiac amyloidosis / PET tracer AT-01 in Phase III and SPECT tracer AT-05 in Phase I of clinical development specifically designed for the diagnosis of cardiac as well as other types of systemic amyloidosis […]

In July 2025, a team of researchers from HITS and the Max Planck Institute for Polymer Research (MPIP) developed a model that learns how to generate proteins with highly flexible structures. A new, complementary deep learning model — Back Bone Flow (BBFlow) — can now predict the dynamics of proteins, providing insights into how they function. Their […]

A new single-cell map reveals how human reproductive organs form and respond to environmental influences New research has mapped the cell types that specialise to form reproductive organs in both sexes, identifying key genes and signals that drive this process. The findings offer important insights into conditions affecting the reproductive organs and how environmental chemicals […]

Can the weakened immune systems of older individuals be rejuvenated? Researchers from the German Cancer Research Center (DKFZ), HI-STEM*, and the Broad Institute have demonstrated that this is possible with an innovative approach. In a study now published in Nature, the team showed that mRNA technology can be used to transform the liver in mice […]

S. A. Iakab, J. Cordes, T. Enzlein, et al. “ From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models.” Adv. Sci. (2025): e16098. https://doi.org/10.1002/advs.202516098 Abstract Human 3D cell cultures, including spheroids and organoids, are essential biological models for translational pharmaceutical and biomedical research. However, their 3D analysis […]

Role of neural cells in tumor progression is becoming ever more evident. HI-STEM scientists published a landmark study in Nature elucidating the role of neural innervation in promoting the tumor progression in pancreatic cancer and how this cross-talk works. Now this study has been featured in an Outlook article in Nature Magazine. Full article can be […]

Full text in German below. Eine Studie stellt die molekulare Verbindung zwischen Tumorstoffwechsel und Wirkstoffbindung in Krebszellen her Madison, WI USA. (09. Dezember 2025) Eine neue Studie, veröffentlicht in Nature Communications, zeigt technologische Vorteile, die Durchbrüche in der Präzisionsmedizin beschleunigen. Durchgeführt wurde sie als Zusammenarbeit zwischen Promega, dem Center for Advanced Study of Drug Action an der […]