bioRN Lounge featuring Agnese Loda – Research Scientists at Heard Group, EMBL

‘Life with two X chromosomes’
• X-chromosome inactivation compensates the difference in X-linked gene dosage between females (XX) and males (XY)
• X-linked genes that escape X-inactivation contributes to sex differences in many contexts including sex-biased disease predisposition
• Escape from X-inactivation is directly modulated by levels of Xist non-coding RNA