Developing New Platforms and Workflows to Support Diversity in Drug Modalities

Developing New Platforms and Workflows to Support Diversity in Drug Modalities
Join us for an exciting talk on the increasing diversity of therapeutic modalities driven by new insights into biological systems. Dave Madge will explore emerging target classes such as protein–protein and protein–nucleic acid interactions, which require novel strategies that combine the stability and cell penetration of small molecules with the selectivity and potency of biologics. The presentation will also highlight how evolving design, synthesis, and testing approaches—as well as new platforms and screening cascades—are enabling these opportunities to be realized.
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How is TR-FRET Used in Drug Discovery?

How is TR-FRET Used in Drug Discovery?

This post is Part 2 of a two-part blog series. Read part 1: What is a TR‑FRET assay and how is it used in drug discovery? In a previous blog post, we covered the fundamental principles of Time-Resolved Fluorescence (TR) Förster Resonance Energy Transfer (TR-FRET), including how long-lived lanthanide donors like europium enable high-sensitivity, “mix-and-read” assays. Because TR-FRET provides a ratiometric, proximity-based […]

Triple ERC Success at the German Cancer Research Center

Triple ERC Success at the German Cancer Research Center

Three researchers at the German Cancer Research Center (DKFZ) have each been awarded a Starting Grant from the European Research Council (ERC) this year. Daniel Kirschenbaum, Lena Kutscher, and Michael Scherer impressed the ERC with their innovative research approaches to fundamental questions in cancer medicine. With the funding, they plan to investigate why certain brain […]

Cancer Cachexia: How a Tumor Protein Drives Wasting in the Body

Cancer Cachexia: How a Tumor Protein Drives Wasting in the Body

Researchers at Helmholtz Munich, the Heidelberg Faculty of Medicine at Heidelberg University, the German Center for Diabetes Research (DZD) and the Technical University of Munich (TUM) have identified a previously unknown mechanism that can drive cancer cachexia – a wasting process in the body that primarily affects muscle and fat tissue. A central role is […]

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