Webinar: Surfactant Strategies for Biopharmaceutical Stability and Performance
Surfactants play a critical role in maintaining the physical stability of therapeutic protein formulations, yet commonly used polysorbates are prone to degradation that can lead to particle formation and stability challenges.
In this webinar, we explore Poloxamer 188 variants as an alternative surfactant strategy, focusing on how increased hydrophobicity influences formulation performance and protein stability. Comparative data demonstrate how hydrophobic Poloxamer 188 reduces aggregation, minimizes protein adsorption to PDMS‑containing packaging, and avoids enzymatic degradation pathways seen with polysorbates.
Attendees will gain practical insights into excipient selection and formulation design strategies to enhance biologic drug product quality and long‑term stability.
Key takeaways:
- Different P188 grades have tailored responses for specific applications in both upstream and formulation
- Advantages of more hydrophobic Poloxamer 188 variant
- Critical impact of increasing poloxamer hydrophobicity on PDMS‑containing primary packaging
