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Helmholtz Institute for Translational AngioCardioScience brings together expertise in cardiac, vascular and systems biology Prof. Dr Karina Yaniv of the Weizmann Institute of Science has been appointed as new Scientific Director of the Helmholtz Institute for Translational AngioCardioScience in Mannheim/Heidelberg (HI-TAC), the Max Delbrück Center in Berlin and Heidelberg University announced in cooperation with the […]

NK Cell Immunotherapy offers New Hope for Fibrosis Research jointly led by scientists at the Heidelberg site of the German Center for Lung Research and investigators in Boston at Massachusetts General Hospital and Harvard Medical School identifies a new immunotherapy-based approach for lung fibrosis: reactivating natural killer cell (NK cells) to eliminate senescent fibroblasts, reverse […]

In a paper newly published in mAbs, Universität Stuttgart-, Technical University of Braunschweig-, and YUMAB GmbH-based authors reveal research results for novel antagonistic anti-EGFR antibodies that have potential to overcome resistance to current T-cell engagers against the same target. ABSTRACT Epidermal growth factor receptor (EGFR) is a validated therapeutic target in several human cancers harboring […]

Nature Neuroscience study identifies human plaque-associated microglia using deep learning-based cell segmentation

Researchers’ newest technologies allow them to discover tiny protein that plays a big role in awakening dormant cells when it’s safe to resume normal operations Summary It’s a tough world for microbes. When resources grow limited and environments worsen, microbes have figured out ways to hunker down and go dormant until conditions improve. However, scientists […]

An international consortium has found over 1,700 new proteins from noncoding DNA, many of which show potential as targets for cancer immunotherapy In a collaborative effort, scientists in the TransCODE consortium reveal more than 1,700 new proteins that could have implications for human diseases, including cancer. These tiny proteins were found in what’s called the […]

The ability of cancer cells to change their identity makes tumors such as glioblastoma particularly aggressive and resistant to treatment. Moritz Mall, of the German Cancer Research Center (DKFZ) and the Hector Institute for Translational Brain Research (HITBR), is investigating how this plasticity can be specifically restricted. His approach focuses on genetic “guardians” that suppress […]

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). They show that there are not just one, but four different subtypes of leukemia stem cells. This diversity could explain why one of the most important […]

Whether people try to quit smoking depends heavily on public health policies in their respective countries – whether they are successful, however, depends primarily on their personal environment and behavior. This was the finding of researchers from the German Cancer Research Center (DKFZ) in an international study. The researchers analyzed data from over 50,000 smokers […]