Research

Researchers at the German Cancer Research Center (DKFZ) have succeeded in identifying a resistance mechanism that often occurs in a specific targeted therapy against chronic lymphocytic leukemia (CLL). The drug ibrutinib is effective in many cases, but therapy resistance often develops during the course of treatment. In cell culture experiments and in mice, the resistance […]

WuXi AppTec is a pharmaceutical, biotechnology, and medical device R&D service provider with operations in China and the U.S. Its China-based services cover the entire discovery and development process, from hit-to-lead and preclinical development to clinical drug production and commercialization. In the U.S., the company offers integrated laboratory and manufacturing services for biologics and medical […]

Researchers at the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) have developed a promising cellular immunotherapy for the treatment of glioblastomas: They equipped T cells with a receptor that recognizes a protein of the brain tumors that is responsible for the dangerous stem cell properties. The therapeutic T cells directed […]

Synthetic biologists from Heidelberg University create nanotubes folded from the natural RNA biomolecule With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology work with RNA origami. This tool uses the multifunctionality of the natural RNA biomolecule to fold new building blocks, making protein synthesis superfluous. In […]

miR-Blood is capable of revealing highly cell-type specific patterns of small RNA expression HEIDELBERG, Germany, March 06, 2024 – Hummingbird Diagnostics GmbH, a leader in using blood-based small RNAs for early disease detection and characterization, today announced a publication in Scientific Data, a peer-reviewed, open-access journal launched by Nature. The study evaluated miR-Blood, Hummingbird Diagnostics’ […]

The weight of expectant mothers could play a role in the development of acute lymphoblastic leukemia (ALL) in daughters – but not in sons. This has been shown by researchers at the German Cancer Research Center (DKFZ). Acute lymphoblastic leukemia is rare overall, but accounts for about a quarter of childhood cancers. To identify possible […]

Third funding phase for collaboration between research and industry – BMBF funds five-year project with ten million euros The goal of the interdisciplinary research campus “Mannheim Molecular Intervention Environment” (M²OLIE) is to provide tailored treatment for cancer patients with oligometastases that is both minimally invasive and efficient. Based at the Mannheim University Hospital, 25 research […]

Another EMBL-engineered advance to Brillouin microscopy significantly widens the aperture and provides for quick, more efficient 3-D imaging of light-sensitive samples Summary A new paper updates an EMBL technology advance even further. More details about the original technology can be found in our initial reporting here. EMBL tech developers have made an important leap forward with […]

Donating blood saves lives – but what long-term effects does this practice have on our bodies? Researchers from the German Cancer Research Center (DKFZ), the HI-STEM stem cell institute* and the German Red Cross Blood Donor Service, among others, have now discovered that frequent blood donations cause genetic adaptations in blood stem cells that promote […]