September 18, 2026
New Publication by Gen-H: Multi-plasmid antibiotic-free fermentation
Our latest publication demonstrates a robust strategy for antibiotic-free maintenance of multiple plasmids using orthogonal conditional complementation.
You can read the article here.
Key highlights:
✅ Maintenance of two plasmids without antibiotics or resistance markers
✅ Functionality in non-supplemented media
✅ Flexible one- or two-plasmid configurations using orthogonal inducible promoters
✅ Productivity equivalent or superior to conventional antibiotic-selected systems
These results further establish conditional complementation as a versatile platform for plasmid maintenance and provide a practical, antibiotic-free solution for complex multi-plasmid biosynthetic pathways.
